Our group develops methods in the theory and computational modeling of nanoscale devices, and applies them to emerging technologies. In particular, we are interested in emerging devices where quantum mechanics plays a fundamental role in determining device behavior. Such devices have the potential to impact the fields of low power electronics and bio/chemical sensing technologies. We use both methods developed by us and other groups to design and simulate nanodevices and explain experiments. Our current research involves charge transport in (i) emerging memory devices where atom movement is central to information storage, (ii) bio nanostructures (DNA and peptides), (iii) molecular nanostructures and (iv) solar cells. Read More
Our lab studies the mitotic spindle, a molecular machine that organizes and separates duplicated chromosomes during cell division, thereby ensuring equal partitioning of the genetic material. To uncover how this machine operates, we are reconstituting spindle functions using pure components and applying new biophysical tools for manipulating and tracking individual molecules, such as laser trapping and ultrasensitive fluorescence microscopy. Read More
Professor Baker's research aims to predict the structures of naturally occurring biomolecules and interactions and to design new molecules with new and useful functions. Building on intial computational designs, Baker uses experiment to better understand the principles underlying catalysis and binding in order to design novel proteins and enzymes. Read More
Research in the Baneyx laboratory lies at the confluence of synthetic biology, nanotechnology, molecular engineering and materials science. We are a lead lab in CSSAS, the Center for the Science of Synthesis Across Scales, an Energy Frontier Research Center (EFRC) directed by Prof. Baneyx that brings together investigators from six universities and a national laboratory. Inspired by nature’s ability to fabricate intricate and often hierarchical materials with outstanding transport, optical, and magnetic properties, we seek to understand the rules that underpin the interaction of combinatorially-selected solid-binding peptides with inorganic and synthetic interfaces. Read More
In our lab, we work on many aspects of micro and nano electro mechanical systems (MEMS / NEMS). This research tends to be very interdisciplinary, and we have collaborations in biology, chemical engineering, bioengineering, computer science, and other departments. We have built, for example, self-assembling microstructures, biomedical implants, systems for docking of picosatellites, and walking microrobots. Read More
Reversible enzymatic modifications of protein side-chains, also known as post-translational modifications or PTMs, confer complexity to biological systems by dynamically regulating the location, structure, and activity of proteomes. Elucidating the mechanistic contributions of post-translationally modified proteins to key cellular processes, such as gene transcription, is critical for understanding normal human development and to identify new therapeutic targets in diseases arising from the misregulation of PTMs. To accomplish these goals, we apply a seamless combination of chemical and molecular biological tools to investigate uniformly modified proteins in well-defined biophysical and biochemical systems. Read More
Dr. Gamble's research focuses on surface modification and characterization of model biomedical systems including fundamental research towards the preparation and characterization of DNA and protein microarrays. She is also involved in the development of new techniques that will enable improved analysis of the biomolecule-surface interface and improved chemical imaging of biologically relevant samples. Read More
Our group designs and develops functional materials and structures on the nanometer scale. Examples include multicolor quantum dots for fluorescence imaging, magnetic nanoparticles for MRI, metallic nanoparticles for ultrasensitive detection, and polymeric nanoparticles for targeted drug delivery. Most recently, we are developing multimodality imaging probes by combining different materials into discrete nanostructures in order to utilize the strength of each individual component. Read More
Our lab studies how immune cells make fate decisions, both as they develop from stem cells, and as they respond to antigens. We combine live cell imaging, mathematical modeling and other modern approaches to dissect the molecular circuitry underlying fate control at the single cell level. Our work will lay foundations for engineering immune cells to treat cancer and other life-threatening diseases. Read More