MolE Alum receives 2020 Graduate School Dissertation Award

Recent MolE program alum Dan Lee was awarded the 2020 Distinguished Dissertation Award in mathematics, physical sciences and engineering from the UW Graduate School for his dissertation, "Synthesis of novel backbone functional polymers." As a graduate student in Suzie Pun's lab, Dan developed easily synthesized, biocompatible hydrogels that can conduct electricity and could be used to engineer cardiac or neural tissues among other applications. In this profile from the UW Graduate School, Dan shares how he found opportunities to innovate as a scientists and molecular engineer when things didn't go according to plan.

Designing proteins that can sequence DNA

Sinduja Marx has long been interested in developing miniaturized, parallelized and personalized sequencing and diagnostics tools. As a molecular engineering grad student in the labs of physics professor Jens Gundlach, and Institute for Protein Design director David Baker, Marx is designing synthetic biological channels for nanopore DNA sequencing and molecular diagnostics. In this Q&A, Marx talks about her research and advice for prospective grad students.

Researchers identify rules for effectively regulating gene expression in bacteria

Jason Fontana, a molecular engineering Ph.D. student in the labs of chemical engineering professor James Carothers and chemistry professor Jesse Zalatan, has identified features of bacterial genes that impose strict requirements on CRISPR-Cas transcriptional activation tools. This work defines new strategies to effectively regulate gene expression in bacteria, bringing researchers closer to their goal of using bacteria to produce valuable biosynthetic products. Read this Q&A with Jesse Zalatan featured on the Science in Seattle blog.

Hail to the fiber king

Student jumping in graduation regalia
Hao Shen pioneered the creation of self-assembling protein fibers from scratch in the lab of UW Biochemistry professor David Baker. Hao was part of our first cohort of students and is the first student to receive a PhD in molecular engineering from the University of Washington. Read more about Hao's scientific journey!

Synthetic peptide can inhibit toxicity, aggregation of protein in Alzheimer's disease, researchers show

A team led by MolES faculty member and bioengineering Professor Valerie Daggett has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer's disease. Dylan Shea, a molecular engineering PhD student in the Daggett lab, was the lead author on a new paper describing these findings, published April 19 in the Proceedings of the National Academy of Sciences.

Scientists design protein filaments that snap themselves together like Lego blocks

Hao Shen, a molecular engineering PhD candidate in the lab of biochemistry Professor David Baker, was a lead author of a study published in Science describing the creation of self-assembling protein filaments from scratch. The filaments were built from identical protein subunits that snap together spontaneously to form long, helical, thread-like structures which could be used to create new materials for a range of applications, from diagnostics to nano-electronics. Learn more in a related Geekwire story!

Navigating interdisciplinary research as a MolE PhD student

Ty Jorgenson in the lab pipetting
At the intersection of genetic engineering and nanoscience, second-year MolE PhD candidate Tyler (Ty) Jorgenson is developing a set of design rules for devices that join biology with solid-state materials. His research focuses on the self-assembly of solid-binding peptides and their interfaces with single-layer atomic (2D) materials, which he says is particularly promising for bioelectronic devices.

Nanotech/Molecular Engineering Students Win Biz Plan Competition

Congratulations to Charlie Corredor and Renuka Ramanathan for their success in the 2015 UW Business Plan Competition. Each was a member of a team that won a seed money for their start-up businesses. Both Charlie and Renuka are Ph.D. candidates in the dual title degree in Nanotechnology & Molecular Engineering offer through the MolES Institute.