Ellie James

Medicinal Chemistry

Neurodegenerative diseases like Alzheimer’s and ALS are characterized by the aggregation of disordered proteins. Recent discoveries suggest that these same disordered proteins also demonstrate phase separation behavior, in which disordered proteins prefer each other to mixing evenly in aqueous solution. Working with Professors Abhi Nath and Mike Guttman in the department of Medicinal Chemistry, Ellie seeks to understand the dynamics and structural intricacies that govern aggregation and phase separation. This knowledge may enable the use of small molecule drugs to influence disordered proteins on the pathways to aggregation or phase separation. Ellie holds a B.S. in Biochemistry and a minor in Materials Science from Western Washington University.