All FacultyWei WeiInstitute for Systems Biologywwei@systemsbiology.org206-732-1221Department ProfileLab Website The Wei lab focuses on highly cross-disciplinary research within the realms of molecular and cellular analysis and cancer systems biology. Our areas of focus include the development and implementation of innovative single-cell multi-omics tools and systems-level computational approaches, aimed at unraveling the complexities of tumor heterogeneity and the tumor-immune microenvironment (TME). We are engaged in exploring treatment-induced cell lineage state transition, epigenetic plasticity, and signaling network dynamics, which are key factors in the development of adaptive therapy resistance in cancer. Additionally, our lab is at the forefront of functional precision medicine, utilizing tumor-derived materials from liquid biopsy and needle biopsy samples for predictive cancer diagnostics and immunotherapy. This integrative approach allows us to investigate cutting-edge questions in cancer biology, bridging molecular insights with clinical applications.