Linda Wordeman

Physiology and Biophysics

We use high resolution live imaging and total internal reflection microscopy to study molecular motors and their role in mitotic spindle assembly and chromosome movement. At the single molecule level we evaluate motor control of dynamic microtubule assembly and disassembly. Of special interest are the forces driving oscillatory chromosome movement, mitotic spindle assembly and mitotic spindle orientation in live cells. Finally, we are interested in the advection of motors in live cells. In other words, how the kinetic parameters of single microtubule motors influences their translocation, distribution and function in cells and we are interested in modeling this activity in silico.