The Heath lab has been developing new biomolecular engineered library technologies for the high throughput capture and analysis of antigen-paired CD8+ and CD4+ T cell receptors. (Foy, Nature 2023; Puig-Saus, Nature 2023; Chour; CommBio 2023) We are currently using these molecular engineered libraries to identify T cell receptors in projects that are supporting clinically deployed TCR-engineered T cell cancer immunotherapies, as well as fundamental biological studies, using spleen organoids, of the development of adaptive immunity following various vaccination treatments. these biomolecular engineering and immunology projects are accompanied by state-of-the-art computational biology algorithm development and application.