The Zalatan research group seeks to understand how biological signaling networks are organized at the molecular level to process, integrate, and coordinate signals. We focus on individual reaction steps at key decision points in cell signaling pathways, using a wide range of tools from biochemistry, enzymology, and synthetic biology. This approach allows us to draw connections between molecular events and cellular behaviors, providing a framework to identify new drug targets and to engineer synthetic pathways for cell-based therapeutics and devices.