David Shechner


My laboratory aims to decipher and manipulate the molecular mechanisms by which mammalian cells establish and utilize higher-order chromatin structures, with an emphasis on the interplay between noncoding RNAs (ncRNAs) and nuclear architecture. Towards this end, we are developing a suite of novel technologies for probing and exploiting ncRNA function in situ, including methods for targeting artificial ncRNA devices to chromatin. Combined with an array of biochemical, genomic, and chemical biological techniques, we aim to elucidate the mechanisms by which ncRNAs influence nuclear organization at all levels. This will enable new routes towards novel RNA-based and RNA-focused biotechnologies and therapeutics.