Douglas Fowler

Douglas Fowler

How does a protein’s sequence encode its fold and function? How do changes in sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication? The Fowler lab develops new ways to probe the relationship between genotype and phenotype, enabling us to better answer these questions. To accomplish this goal, we draw on our expertise in genomics, protein science, technology development and computational approaches. Read More

Jay Shendure

The Shendure Lab is part of the Howard Hughes Medical Institute and the Department of Genome Sciences at the University of Washington (Seattle, WA). The mission of our lab is to develop and apply new technologies and methods for genetics, genomics and molecular biology. Most of our work exploits next-generation DNA sequencing which is effectively emerging as a broadly enabling microscope for the measurement of biological phenomena. Our ongoing work generally falls into six areas: developing new molecular methods, genomic approaches to developmental biology, massively parallel functional genomics, translating genomics to the clinic, genetic basis of human disease and genome sequencing technologies. Read More

Will Chen

As a graduate student in the lab of genomics professor Jay Shendure, Will developed tools to better understand development and gene regulation. Using CRISPR/Cas9, he engineered tools that can record biological events in cells, providing researchers a window into molecular events that occurred while the cells were going through development and differentiation. He also developed a computational tool, known as Lindel, to accurately predict the genome editing outcomes of CRISPR/Cas9. He holds a B.S in Biological Science from Shandong University, China and a M.S Read More

Ruihong Wang

Ruihong “Redd” Wang was co-advised by bioengineering professor Michael Jensen and genome sciences professor John Stamatoyannopoulos. Redd developed a new platform for high-throughput functional genotyping of regulatory elements at the single cell level. He is currently a research scientist at the Altius Institute for Biomedical Sciences. Read More

Raymond Monnat

The Monnat Lab is interested in the molecular basis of human disease, and how synthetic and engineering approaches can be used to understand, treat or prevent disease. Our specific research projects have focused on cancer biology and therapy, and on building genome engineering tools to enable cellular and synthetic biology disease applications. Read More