Professor Yager's research interests lie in the areas of: microfluidic devices for chemical and biochemical measurement., development of point-of-care diagnostic instruments, microfabrication technologies for microfluidics, and development of microfluidic-specific methods of analysis of biological samples. Read More
Our goal is to hijack and rewire aspects of nature's developmental programs to control the processes by which cells assemble to form human tissues. We are also working to develop technologies to remotely control these tissues after implantation in a patient. To do this, we use diverse tools from stem cell biology, tissue engineering, synthetic biology, microfabrication, and bioprinting. We seek to translate our work into new regenerative therapies for patients with heart and liver disease. Read More
The Daggett Laboratory focuses on studies of both bacterial and mammalian proteins involved in amyloid diseases. We use a variety of biophysical, biochemical, analytical, biological and computational techniques to investigate the conformational changes behind these devastating diseases. In turn, we use what we learn for the design and development of diagnostics and therapeutics. Read More
We design and use microfluidic devices to better mimic the real microenvironment of nerve and cancer cells when we culture them outside of the organism. We are microfluidic! Examples of questions that interest us are how neurons find their targets during development (axon guidance), how they establish their connections (synaptogenesis), and how we sense odors (olfaction), among other projects. We also build microfluidic devices that allow us to personalize chemotherapy and devices to study cancer stem cells. Read More
Our lab is developing molecular agents and systems for photoacoustic and ultrasonic molecular imaging. Also, we look at integrated therapeutics for molecular-level theransotics (i.e., integrated diangostics and therapy). Read More
The Berndt lab develops fluorescent biosensors for optogenetic approaches by utilizing structure guided and high throughput protein engineering. We aim to detect the activity of neurotransmitter, neuromodulators, hormones, ions and intracellular signaling molecules in life tissue and behaving animals. These sensors will provide multidimensional real time information of the current state of neurons and neuronal networks. Our goal is to identify impaired network dynamics in rodent models for neurological disorders. However, these protein tools are universally applicable and we seek to expand applications into other cell types such as cardiac, pancreatic and stem cells. Read More