New system outcompetes traditional biofactories with on-demand, remote chemical production

two men sitting at table looking at hydrogels
A team was led by Dr. Alshakim Nelson, an assistant professor of chemistry at the UW, and Dr. Hal Alper, a professor of chemical engineering at the University of Texas, developed a new method that combines the bioactivity of microbes and a 3D-printed, synthetic hydrogel "” a water-based gel structure "” to create desired chemical compounds. The products can vary from pharmaceuticals to nutraceuticals, alluding to the vast potential for this new finding.

First-of-its-kind hydrogel platform enables on-demand production of medicines and chemicals

a water-based gel that is used in molecular biology research
Researchers in the lab of MolES faculty member and professor of chemistry Al Nelson along with collaborators at the University of Texas unveiled a new way to produce medicines and chemicals and preserve them using portable "biofactories" that are embedded in water-based gels known as hydrogels. The approach could help people in remote villages or on military missions, where the absence of pharmacies, doctor's offices or even basic refrigeration makes it hard to access critical medicines and other small-molecule compounds.

Light-based "˜tractor beam' assembles materials at the nanoscale

A team led by MolES faculty member Peter Pauzauskie, a professor of materials science and engineering, has developed a method that could make reproducible manufacturing at the nanoscale possible. The team adapted a light-based technology employed widely in biology "” known as optical traps or optical tweezers "” to operate in a water-free liquid environment of carbon-rich organic solvents, thereby enabling new potential applications.

New technique lets researchers map strain in next-gen solar cells

A team led by David Ginger, professor of chemistry and MolES faculty member, has developed a way to map strain in lead halide perovskite solar cells. Their approach shows that misorientation between microscopic perovskite crystals is the primary contributor to the buildup of strain within the solar cell, which creates small-scale defects in the grain structure, interrupts the transport of electrons within the solar cell, and ultimately leads to heat loss through a process known as non-radiative recombination.

New metasurface design can control optical fields in three dimensions

A team led by MolES faculty member Arka Majumdar, an assistant professor of electrical and computer engineering and physics, has designed and tested a 3D-printed metamaterial that can manipulate light with nanoscale precision. As they report in a paper published October 4 in the journal Science Advances, their designed optical element focuses light to discrete points in a 3D helical pattern.

Scientists can now control thermal profiles at the nanoscale

In a paper published online July 30 by the journal ACS Nano, David Masiello, MolES faculty member and professor of chemistry, and colleagues from Rice University and Temple University, report a new breakthrough on controlling the thermal profiles of materials at the nanoscale. The team of researchers designed and tested an experimental system that uses a near-infrared laser to actively heat two gold nanorod antennae "” metal rods designed and built at the nanoscale "” to different temperatures. The nanorods are so close together that they are both electromagnetically and thermally coupled. Yet the team measured temperature differences between the rods as high as 20 degrees Celsius. By simply changing the wavelength of the laser, they could also change which nanorod was cooler and which was warmer, even though the rods were made of the same material.

First-ever visualizations of electrical gating effects on electronic structure could lead to longer-lasting devices

For the first time, scientists have visualized the electronic structure in a microelectronic device, opening up opportunities for finely tuned, high-performance electronic devices. UW physicists David Cobden and Xaiodong Xu, in collaboration with colleagues at the University of Warwick, developed a technique to measure the energy and momentum of electrons in operating microelectronic devices made of atomically thin "” so-called 2D "” materials. Their findings, published last week in the journal Nature could lead to new, finely tuned, high performance electronic devices.

Scientists use molecular tethers and chemical "˜light sabers' to construct platforms for tissue engineering

In a paper published May 20 in the journal Nature Materials, a research team led by MolES faculty member Cole DeForest unveiled a new strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to the scaffold using light. Since the tether can also be cut by laser light, this method can create evolving patterns of signal proteins throughout a biomaterial scaffold to grow tissues made up of different types of cells.