Scientists solve chemical mystery at the interface of biology and technology

Researchers who want to bridge the divide between biology and technology spend a lot of time thinking about translating between the two different “languages” of those realms. “Our digital technology operates through a series of electronic on-off switches that control the flow of current and voltage,” said Rajiv Giridharagopal, a research scientist at the University of Washington. “But our bodies operate on chemistry. In our brains, neurons propagate signals electrochemically, by moving ions — charged atoms or molecules — not electrons.”

AI shown to dramatically speed protein engineering

Study findings promise to shift the field away from trial-and-error approach and toward computational approaches. Protein engineering scientists have been able to use machine learning to design proteins that are more efficient at performing a biochemical task. This approach shortened a process that typically takes months to years of trial and error.  Currently, researchers design proteins by introducing mutations into a protein’s amino acid sequence in the hope those mutations will give the protein a desired property or function. They then must repeatedly test the resulting mutant proteins in the lab.