Debbie Nickerson

Genome Sciences

For more than a decade, my group has been interested in the identification and typing of common sequence variations in the human genome known as single nucleotide polymorphisms (SNPs) in an effort to gain an understanding of the patterns of sequence variation in human genome and to improve approaches for association mapping of common human diseases. In collaboration with a number of groups, we are exploring the genetics of cardiovascular disease risk in human populations. We are also developing and testing novel SNP and haplotype-based approaches for association mapping in humans, and we are exploring the relationships that may exist between genotype and trait expression at the RNA and protein levels in humans.